تاثیر کلونیدین در کاهش خونریزی در اعمال جراحی آندوسکوپی سینوس، بیمارستان امیراعلم، 79-1377

This study was conducted to evaluate effect of clonidine as a premedication on endoscopic sinus surgery bleeding.Methods and Materials: during a randomized double blind clinical trial we compared two groups of patients who scheduled for endoscopic sinus surgery for polypectomy and etmoidectomy. 216 patients randomly assigned in two groups.In first group 2 hours befor surgery a 0.2mg tablet of clonidine orally adminestered to patients and in second group a 100 mg tablet of vit Bj(with same size and color- asplacebo)was adminestered to patients. The amount of bleeding measured in two groups.Results: mean bleeding volume in clonidine group was 113+76 ml and in control group was 211 + 113 ml. There was a significant statistical difference between two groups (pO.0001).Conclusion: Clonidine as premedication can reduce bleeding of endoscopic sinus surgery significantly.